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来源:河北大学 2019-08-19 相关院校:河北大学
河北大学化学与环境科学学院研究生导师李胜辉介绍如下:
一、个人简介
李胜辉:男,理学博士,教授,硕士导师。2005年毕业于中国科学院化学研究所,主修聚合物化学与物理。自1995年工作以来,我参加了许多国家自然科学基金、科技部973计划和中国科学院的初步研究项目“引进国外优秀人才,百人计划”主持河北省自然科学基金2项。目前主要从事基于生物的生活
金属有机超分子和具有抗肿瘤活性的天然有机小分子类似物的设计、合成和作用机制研究。先后在Organ. Lett., Bioorg. Med. Chem. Lett.,Curr. Organ. Chem.,Dalton Trans., Inorg. Chem., Inorg. Chem. Commun.,杂志上发表了30多篇学术论文。
email:lish@hbu.edu.cn
二、讲座课程及研究方向
1.主课:有机化学、物理有机化学
2.研究方向:化学生物学、超分子化学
三、科研项目
1. 河北自然科学基金:11个目标G-4链-N-甲基消炎[2,3-b]设计、合成、抗肿瘤活性研究(项目编号:B2015201213, 2015-2017,主持人)
2. 河北自然科学基金-石药集团医学联合研究基金:多金属中心G-4链结合剂的设计、合成和抗肿瘤活性研究(项目编号:B201120174, 2011-2013,主持人)
3. 科技部973计划初步研究项目:基于DNA靶标的多效抗肿瘤药物研究(项目编号:2010CB534913、2010-2012、第六参与者)
4. 河北自然科学基金:制备功能多孔配位聚合物(项目编号:B200700152、2007-2009,第二完成人)
5. 横向课题-“开发新型染料中间体” (项目编号:2008-15,主持人)
四、代表性论文
1. Shenghui Li*, Shengjie Xu, Yonghe Tang, Shan Ding, Jinchao Zhang, Shuxiang Wang, Guoqiang Zhou, Chuanqi Zhou, Xiaoliu Li, Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives, Bioorg. Med. Chem. Lett., 2014, 24(2), 586-590.
2. Shenghui Li ,Shengjie Xu, Shan Ding, Jinchao Zhang,Shuxiang Wang, Xiaoliu Li,Synthesis and biological evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents,Res Chem Intermed, 2014, 40(4), 1459-1468.
3. Shenghui Li, Shan Ding, Shengjie Xu, Jinchao Zhang, Shuxiang Wang, Chuanqi Zhou, Xiaoliu Li, Iodine-catalyzed three-component one-pot synthesis of novel 1,8-dioxo-decahydroacridines derivatives bearing benzene sulfonamide moiety, Res Chem Intermed, 2014, 40(5), 2091-2102.
4. Shengjie Xu, Shenghui Li*, Yonghe Tang, Jinchao Zhang, Shuxiang Wang, Chuanqi Zhou, Xiaoliu Li, Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents, Med Chem Res, 2013, 22, 5610-5616.
5. Shu-Yan Yu; Qing Jiao; Sheng-Hui Li; Hai-Ping Huang; Yi-Zhi Li; Yuan-Jiang Pan; Yoshihisa Sei; and Kentaro Yamaguchi; Self-Assembly of Tripyrazolate-Linked Macrotricyclic M12L4 Cages with Dimetallic Clips, Organic Letters, 2007, 9(7): 1379-1382
6. LI Sheng-Hui; HUANG Hai-Ping; YU Shu-Yan; LI Xian-Ping, Design and Synthesis of Polypyrazolyl Compounds as a New Type of Versatile Building Blocks, Chinese Journal of Chemistry, 2006, 24, 1225-1229
7. Sheng-Hui Li; Hai-Ping Huang; Shu-Yan Yu*; Yi-Zhi Li*; Yoshihisa Sei, Kentaro Yamaguchi, Self-assembly of coordination molecular baskets as inorganic analogues of cyclotriveratrylenes (CTV), Dalton Transactions, 2005, 2346-2348.
8. Shu-Yan Yu*; Sheng-Hui Li; Hai-Ping Huang; Zhong-Xing Zhang; Qing Jiao; Hong Shen; Xi-Xue Hu; Hui Huang; Molecular Self-Assembly with Modularization and Directionality: Vector-Manipulation at Metal Centers, Current Organic Chemistry, 2005, 9, 555-563
9 Shu-Yan Yu, Hai-Ping Huang, Sheng-Hui Li, Qing Jiao, Yi–Zhi Li, Biao Wu, Yoshihisa Sei, Kentaro Yamaguchi, Yuan-Jiang Pan and Hong-Wei Ma, Solution Self-Assembly, Spontaneous Deprotonation, and Crystal Structures of Bipyrazolate-Bridged Metallomacrocycles with Dimetal Centers, Inorgic
Chemistry, 2005, 44,9471-9488.
10. Hai-Ping Huang; Sheng-Hui Li; Shu-Yan Yu*; Yi-Zhi Li*; Qing Jiao; Yuan-Jiang Pan, Novel pyrazolate-bridged dinuclear Pd(II) diimine complexes that bind inorganic anions, Inorganic Chemistry Communications, 2005, 8, 656-660.
五、获奖情况
1. 一种新型生物标志化合物:甲基三环萜烷合成研究(河北科技奖:三等奖,2002年4月,第五名参与者)
2. 合成与稳定臭氧化物性质研究(河北省科技奖:三等奖,2003年5月,第三参与者)