导师信息#北京大学药学院化学生物学专业硕士研究生导师信息#葛泽梅

葛泽梅：副教授，硕士生导师。

Tel:010-82801504

E-mail:zmge@bjmu.edu.cn

通讯地址：北京市海淀区学院路38号药学楼504室邮编：100191

多年来一直从事有机化学、药物化学 、化学生物学的科研与教学工作 。主要研究方向为基于作用机制的杂环类化合物的设计
、合成、合成方法及生物活性研究
。已主持完成国家自然科学基金2项 ，作为主要参加者完成国家自然科学基金3项以及“973 ”子课题等。目前主持或承担国家“十一五
”“北京大学综合性创新药物研究开发技术大平台”的候选药物研究品种及新药临床前研究课题 。在国内外学术刊物上发表论文40余篇
，申请专利6项
。

主要研究领域：

1.基于作用机制的杂环类化合物的设计 、合成
、合成方法及生物活性研究

2.氨基二硫代甲酸酯类化合物的设计、合成及抗肿瘤活性研究

3.新型酪氨酸激酶抑制剂的设计 、合成及活性研究

4.硫醇替代试剂的应用扩展与研究

代表性论文

1.Ri-DongLi,XinZhang,Qiao-YanLi,Ze-MeiGe*,Run-TaoLi*,NovelEGFRinhibitorspreparedbycombinationofdithiocarbamicacidestersand4-anilinoquinazolines.Bioorg.Med.Chem.Lett.2011,21,3637–3640.

2.Wang,Junfeng;Qi,Chao;Ge,Zemei*;Cheng,Tieming;Li,Runtao*.EfficientdirectasymmetricvinylogousMichaeladditionreactionsofg-butenolidestochalconescatalyzedbyvicinalprimary-diaminesaltsChem.Commun.,2010,46,2124–2126.

3.Wang,Junfeng;Li,Qin;Qi,Chao;Liu,Yi;Ge,Zemei*;Li,Runtao*.Primary1,2-diaminecatalysisIII:anunexpecteddominoreactionforthesynthesisofmultisubstitutedcyclohexa-1,3-dienamines.Organic&BiomolecularChemistry,(2010),8(19),4240-4242.

4.Wang,Junfeng;Wang,Xin;Ge,Zemei*;Cheng,Tieming;Li,Runtao*.HighlyenantioselectiveMichaeladditionofcyclopentanonewithchalconesvianoveldi-iminiummechanism.Chem.Commun.,2010,46,1751–1753.

5.MENGLEI,SHUAIXIA,JUNFENGWANG,ZEMEIGE,*TIEMINGCHENG,ANDRUNTAOLI*，AnEfficientDipeptide-CatalyzedDirectAsymmetricAldolReactionofEquimolarReactantsinSolidMedia ，CHIRALITY,22:580–586(2010).

6.Fang-binHan,Ze-meiGe,*Tie-mingCheng,Run-taoLi*,NovelOne-Pot,Four-ComponentSynthesisof3-Alkyldithiocarbonyl-oxazolidinesfromAminoethanols,Ketones,CarbonDisulfide,andHalides,Synlett.,2009,4,648-650.

7.Zhong-qingWang,Ze-meiGe,*Tie-mingCheng,Run-taoLi*,SynthesisofHighlySubstitutedPyridinesviaaOne-Pot,Three-ComponentCascadeReactionofMalononitrilewithAldehydesandS-AlkylisothiouroniumSaltsinWater,Synlett.,2009,7,2020-2022.

8.Jun-fengWang,MengLei,QinLi,Ze-meiGe,*XinWang,Run-taoLi*,Anovelandefficientdirectaldolcondensationfromketonesandaromaticaldehydescatalyzedbyproline–TEAthroughanewpathway,Tetrahedron.65(2009),4826-4833

9.ZHU,Jirang(朱继让),LI,Ridong(李日东),GE,Zemei*(葛泽梅),CHENG,Tieming(程铁明),LI,Runtao*(李润涛),Synthesisofβ-HydroxySulfidesviaThiolysisofEpoxidesUsingS-AlkylisothiouroniumSaltsasThiolEquivalentsinBasicAqueousMedium,ChineseJournalofChemistry,2009,27,791-796.

10.WANG,Zhongqing(王仲清),GE,Zemei*(葛泽梅),CHENG,Tieming(程铁明),LI,Runtao*(李润涛),AnEfficientFour-Component,One-PotSynthesisofPoly-SubstitutedPyrimidinesinWater,ChineseJournalofChemistry,2009,27,834-838.

11.XuYan,Ze­MeiGe*,Tie­MingChengandRun­TaoLi*,One­potsynthesisof1,3,4­oxadiazole­5­thioethersinwater,JournalofChinesePharmaceuticalSciences17(2008)277-280.

12.Song-wenLin,aQiSun,aRun-taoLi,*a,bTie-mingCheng,aZe-meiGe*a,PotassiumPhosphatePromotedAza-MarkovnikovAdditionofN-HeterocyclestoVinylEsters.Synthesis,2007,13,1933-1938.

13.YanZhao,aZe-MeiGe,*aTie-MingCheng,aRun-TaoLi*a,b,Thia-MichaelAdditionUsingCheapandOdorlessS-AlkylisothiouroniumSaltsasThiolEquivalentsinWater.Synlett.,2007,10,1529-1532.

14.QiSun,Run-TaoLi,WeiGuo,Jing-RongCui,Tie-MingChengandZe-MeiGe,*Novelclassofcyclophosphamideprodrug:Cyclophosphamidespiropiperaziniums(CPSP),Bioorganic&MedicinalChemistryLetters,2006,16,3727-3730.

15.GE,Ze-Mei,LI,Qin,ZHENG,Shao-Jun,CHENG,Tie-Ming,CUI,Yu-Xin,LI,Run-Tao*,FacileOne-potSynthesisofEthyl3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates,ChineseJournalofChemistry,2006,24,381-385.

16.Ze-meiGe,Jia-lingCui,Yan-lingWang,Tie-mingCheng,Run-taoLi*.Amildandefficientsynthesisof4,5-disubstituted3-amino-4-hydroxythiazolidine-2-thionesandS,N-disubstituted1,3,4-thiadiazole-2-thiones.Synthesis,2004,8,1257-1261.