导师信息#北京大学药学院药剂学专业硕士研究生导师信息#刘艳

刘艳副教授,硕士生导师

北京大学药学院药剂学系副主任

北京市海淀区学院路38号，邮编100191

Tel:(+8610)82801508

Email:yanliu@bjmu.edu.cn

1986年在山东大学化学系获得理学学士学位
。1989年在山东大学化学系获得理学硕士学位。同年8月到北京医科大学药学院工作 。1998-2000年到德国雷根斯堡大学化学与药学系工作与学习
。2000年至今 ，任北京大学药学院药剂学系副教授。讲授物理化学、物理药剂学和分散体系的物理化学等本科 、硕士和博士研究生课程 。担任《化学学报》
、《药学学报》、《中国药学杂志》 、《中国新药杂志》
、InternationalJournalofPharmaceutics、Biomaterials等多个学术期刊的评审
。主持或参加的基金项目包括国家自然科学基金 、973重大研究计划
、国家重大新药创制专项新剂型与新释药系统技术平台等。在国内、外学术期刊上发表论文60余篇 。主编教材或专著5部
，主译专著1部，参编教材2部
。申请国家发明专利16项。主持完成了数个药物制剂的研究开发工作 。

研究兴趣

物理药剂学
。主要涉及以下研究领域

1.新型纳米载体系统与靶向给药

2.药用高分子材料的分子设计 、合成与性能评价

3.药物多晶型

代表性论文

1.XiaoningWang,XinruLi,YanxiaZhou,YanLiu*,etal.Synthesis,characterizationandbiocompatibilityofpoly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline)hydrogels.ActaBiomaterialia,2011,7:4149-4159.

2.XinruLi,YuantingYue,YanxiaZhou,YanLiu*,etal.Anoil-freemicroemulsionforintravenousdeliveryofdiallyltrisulfide:Formulationandevaluation.InternationalJournalofPharmaceutics,2011,407:158-166.

3.XinruLi,YanhuiZhang,YatingFan,YanLiu*,etal.Preparationandevaluationofnovelmixedmicellesasnanocarriersforintravenousdeliveryofpropofol.NanoscaleResearchLetters,2011,6:275.

4.XingweiChen,XinruLi,YanxiaZhou,YanLiu*,etal.Chitosan-basedthermosensitivehydrogelasapromisingoculardrugdeliverysystem:preparation,characterizationandinvivoevaluation.JournalofBiomaterialsApplications,onlineonJuly12,2011.doi:10.1177/0885328211406563.

5.YatingFan,XinruLi,YanxiaZhou,YanLiu*,etal.Improvedintestinaldeliveryofsalmoncalcitoninbywater-in-oilmicroemulsions.InternationalJournalofPharmaceutics,2011,416:323-330.

6.YanhuiZhang,XinruLi,YanxiaZhou,YanLiu*,etal.CyclosporineA-loadedpoly(ethyleneglycol)-b-poly(D,L-lacticacid)micelles:preparation,invitroandinvivocharacterizationandtransportmechanismacrosstheintestinalbarrier.MolecularPharmaceutics,2010,7(4):1169-1182.

7.WangFei,LiXinru,ZhouYanxia,YanLiu*,etal.Novelnanoscaledpolyioncomplexmicellesfortargeteddeliveryofrecombinanthirudintoplateletsbasedoncationiccopolymer.MolecularPharmaceutics,2010,7(3):718-726.

8.XinruLi,PingzhuLi,YanLiu*,etal.Novelmixedpolymericmicellesforenhancingdeliveryofanticancerdrugandovercomingmultidrugresistanceintumorcelllinessimultaneously.PharmaceuticalResearch,2010,27(8):1498-1511.

9.XinruLi,XiaoyanLi,YanxiaZhou,YanLiu*,etal.Developmentofpatchandsprayformulationsforenhancingtopicaldeliveryofsinomeninehydrochloride.JournalofPharmaceuticalSciences,2010,99(4):1790-1799.

10.YanhuiZhang,XinruLi,YanxiaZhou,YanLiu*,etal.Preparationandevaluationofpoly(ethyleneglycol)–poly(Lactide)micellesasnanocarriersfororalDeliveryofcyclosporineA.NanoscaleResrarchLetters,2010,5:917-925.

11.XinruLi,QuanYuan,YanqingHuang,YanxiaZhou,andYanLiu*.Developmentofsilymarinself-microemulsifyingdrugdeliverysystemwithenhancedoralbioavailability.AAPSPharmSciTech,2010,11(2):672-678.

12.MingChen,Xin-RuLi,Yan-XiaZhou,YanLiu*,etal.Improvedabsorptionofsalmoncalcitoninbyultraflexibleliposomesthroughintranasaldelivery.Peptides,2009,30:1288-1295.

13KeweiYang,XinruLi,ZhuoliYang,YanLiu*,etal.Novelpolyioncomplexmicellesforliver-targeteddeliveryofdiammoniumglycyrrhizinate:invitroandinvivocharacterization.JournalofBiomedicalMaterialsResearchPartA,2009,87(4):140-148.

14.XinruLi,YanqingHuang,XingweiChen,YanxiaZhou,YanLiu*,etal.Self-assemblyandcharacterizationofPluronicP105micellesforliver-targeteddeliveryofsilybin.JournalofDrugTargeting,2009,17(10):739-750.

15.XinruLi,ZhuoliYang,KeweiYang,YanLiu*,etal.Self-assembledpolymericmicellarnanoparticlesasnanocarriersforpoorlysolubleanticancerdrugethaselen.NanoscaleResrarchLetters,2009,4:1502-1511.

16.ZhuoliYang,XinruLi,KeweiYang,YanLiu*.AmphotericinB-loadedpoly(ethyleneglycol)-poly(lactide)micelles:preparation,freeze-dryingandinvitrorelease.JournalofBiomedicalMaterialsResearchPartA,2008,85(2):539-546.