导师信息#北京大学药学院药物化学专业硕士研究生导师信息#刘振明

刘振明

理学博士
，副研究员

药物化学，药物设计

电话&传真:+86-10-82805514

+86-10-82802724

联系邮箱:zmliu@bjmu.edu.cn

学习经历:

1996-2000理学学士 ，北京医科大学药学院药物化学专业

2000-2005理学博士
，北京大学化学与分子工程学院物理化学专业（导师：来鲁华）

任职和工作经历：

2011年-至今副研究员，北京大学药学院

2005年-2011年讲师 ，北京大学药学院

2007年-2009年“重大新药创制”科技重大专项实施管理办公室

研究方向与兴趣：药物化学与药物设计。我们的研究兴趣主要是:1)发展新的药物设计方法
，并将其应用于药物的发现过程 。2)通过设计和结构修饰生物活性分子针对特定的药物靶标寻求找到新的具有应用价值的活性先导化合物
。

代表性论文和专著：

1.LiuZM,LiB,LiX,ZhangL,LaiL.IdentificationofSmall-MoleculeInhibitorsagainstHumanLeukocyteAntigen-DeathReceptor4(HLA-DR4)throughaComprehensiveStrategy.JChem.Inf.Model.2011,51:326-334.

2.FanD,LiuZM*,JinHW,ZhangLR.ClassificationofCoenzymeaBindingProteinsBasedonCo-FactorBindingModes.ActaPhysChimSin.2011.

3.TianR,LiuZM*,JinHW,ZhangLR,LinWH.TargetIdentificationofIsomalabaricaneTerpenesExtractedfromSponges.ActaPhysChimSin.2011.

4.ZhengZ,LiuZM*.ApplicationoftheHSABPrinciplefortheQuantitativeAnalysisofNucleophilicity/BasicityofOrganicCompoundswithLonePairElectrons.J.ChinPharmaceuSci.2011,20:125-132.

5.BoLi,ZhenmingLiu*,LiangrenZhangandLiheZhang.Multiple-DockingandAffinityFingerprintMethodsforProteinClassificationandInhibitorsSelection.JChemInf.Comput.Sci.2009,50:1589-1601.

6.ZhengZ,LiuZM*,ZhangLR.CombinedMethodforDeterminingReactionTransitionStateGeometryandEnergy.ActaPhysChimSin.2009,25:1439-1442.

7.LiuZM*,HuangCK,FanKQ,WeiP,ChenH,LiuSY,PeiJF,ShiL,LiB,YangK,LiuY,LaiLH.VirtualScreeningofNovelNoncovalentInhibitorsforSARS-Cov3C-LikeProteinase.JChemInf.Comput.Sci.2005,45:10-17.

8.LiuZM*†,LiBandLaiLH.FunctionalClassificationofPhospholipaseA2Family.ActaPhysChim.Sin.2005,21:1143-1145.\

9.KangLG,ZhangXT,XieY,TuYP,WangD,LiuZM,WangZY.InvolvementofestrogenreceptorvariantER-Alpha36,NotGPR30,innongenomicestrogensignaling.MolEndocrinol.2010,24:709-721.

10.KeYR,JinHW,LiuZM,ZhangLR.HomologymodelingandstructurevalidationoftheAdenosineA(1)receptor.ActaPhysChim.Sin.2010,26:2833-2839.

11.ZhuYQ,ZhuXR,WuG,MaYH,LiYJ,ZhaoX,YuanYX,YangJ,YuS,ShaoF,LiRT,KeYR,LuAJ,LiuZM,ZhangLG.Synthesis,invitroandinvivobiologicalevaluation,dockingstudies,andstructure-activityrelationship(SAR)discussionofdipeptidylboronicacidproteasomeinhibitorscomposedofbeta-aminoacids.J.Med.Chem.2010,53:1990-1999.

12.ZhangSW,ShiYW,JinHW,LiuZM,ZhangLR,ZhangLH.CovalentcomplexesofproteasomemodelwithpeptidealdehydeinhibitorsMG132andMG101:dockingandmoleculardynamicsstudy.J.Mol.Model.2009,15:1481-1490.

13.HanD,MengXB,WangLN,LiuH,YaoY,WangZ,YangZJ,LiuZM,LiZJ.Efficientsynthesisofaseriesofnovelfructose-based3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazolederivativesandstudiesofthereactionmechanism.Tetrahedron-Asymmetry.2009,20:399-410.

14.ZhangZL,WuJ,RanFX,GuoY,TianR,ZhouSX,WangXW,LiuZM,ZhangLR,CuiJR,LiuJY.Novel8-deaza-5,6,7,8-tetrahydroaminopterinderivativesasdihydrofolateinhibitor:Design,synthesisandantifolateactivity.EuropeanJ.Med.Chem.2009,44:764-771.

15.WangYM,HuLX,LiuZM,YouXF,ZhangSH,QuJR,LiZR,LiY,KongWJ,HeHW,ShaoRG,ZhangLR,PengZG,BoykinDW,JiangJD.N-(2,6-Dimethoxypyridine-3-Yl)-9-methyl-carbazole-3-sulfonamideasanoveltubulinligandagainsthumancancer.ClinCancerRes.2008,14:6218-6227.

16.LuX,ChenYL,GuoY,LiuZM,ShiYW,XuY,WangXW,ZhangZL,LiuJY.ThedesignandsynthesisofN-1-alkylated-5-aminoaryalkylsubstituted-6-methyluracilsaspotentialnon-nucleosideHIV-1RTinhibitors.BioorgMedChemLett.2007,15:7399-407.

17.ShiYW,LiuZM,JinHW,ZhangLR,ZhangLH.Quantitativestructure-activityrelationshipsofHIV-1integraseinhibitorsofdkas.ActaPhysChim.Sin.2007,23:1393-1398.

18.TianR,JiYB,LiuZM,JinHW,ZhangLR,LinWH.QSARandbindingmodestudyofaseriesofcombretastatinanaloguesastubulininhibitors.ChemJ.ChineseU.2007,28:2150-2155.

19.LiuY,ZhengTF,JinF,ZhouL,LiuZM,WeiP,LaiLH.Designandbioassayofnon-peptidicinhibitorsofSARScoronavirus3C-likeProteinase.ActaChimicaSinica.2007,65:1707-1712.

20.LvW,LiuZM,JinHW,YuXH,ZhangLR,ZhangLH.Three-DimensionalstructureofHIV-1VIFconstructedbycomparativemodelingandthefunctioncharacterizationanalyzedbymoleculardynamicssimulation.OrgBiomolChem.2007,5:617-626.

21.LiuP,GuoHZ,WangWX,ZhangJ,LiN,HanJ,ZhouJP,HuYC,ZhangT,LiuZM,GuoD.CytotoxicditerpenoidsfromthebarkofPseudolarixkaempferiandtheirstructure-activityrelationships.J.NatProd.2007,70:533-537.

22.PeiJF,WangQ,LiuZM,LiQ,YangK,LaiLH.PSI-DOCK:Towardshighlyefficientandaccurateflexibleliganddocking.Proteins.200662(4):934-946.

23.ZhuYQ,PeiJF,LiuZM,LaiLH,CuiJR,LiRT.3D-QSARstudiesontripeptidealdehydeinhibitorsofproteasomeusingcomfaandcomsiamethods.BioorgMedChemLett.2006,14:1483-1496.

24.LaiLH,HanXF,ChenH,WeiP,HuangCK,LiuSY,FanKQ,ZhouL,LiuZM,PeiJF,LiuY.Quaternarystructure,substrateselectivityandinhibitordesignforSARS3C-likeproteinase.CurrPharmDesign.2006,12:4555-4564.

25.PeiJF,ChenH,LiuZM,HanXF,WangQ,ShenB,ZhouJJ,LaiLH.Improvingthequalityof3D-QSARbyusingflexible-ligandreceptormodels.JChemInf.Model.2005,45:1920-1933.

26.HuangCK,GaoY,LiuZM,LiuY,LaiLH.ComparativemolecularfieldanalysisofpyrrolidineinhibitorsforhumancytosolicphospholipaseA2.ActaPhys-ChimSin.2003,19:79-81.