导师信息#西安交通大学研究生导师信息#李相尧

PrincipalInvestigatoratthelevelofProfessor

Jointlyadeputydirectorofalab(实验室副主任),

LabofNeuronalCircuitryandDisease

(神经回路与疾病实验室)

E-mail:lixiangy9@mail.xjtu.edu.cn

Chronicpainisamajorhealthissueinhumansocietycausedmainlybytissueornerveinjury.Thecommonpathologicalconditionsincludespontaneouspain,allodyniaandhyperalgesia.Peripheralsensitizationandcentralplasticityarelikelytocontributetochronicpain.Thelong-termchangeofthesynaptictransmissioninducedbychronicpainhasbeenstudiedalongthesensorypathway,fromtheperipheryreceptors,spinalcordtotheanteriorcingulatecortex.Differentapproacheswillbeemployedtoinvestigatetheneuronalmechanismmediatingthemaintenanceofchronicpain.

NameXiang-YaoLI

SexMale

Birth,1978.1

AddressFrontierInstituteofScienceandTechnology,

Xi’anjiaotongUniversity,

Rm.B316,WestBuildingNo.1,No.99YanxiangRD,Xi’an

Shbbnxi,710054,China

Phone86-29-83395342

E-mail,Leexiangyao@gmail.com

Education:

2002-2007,Ph.D

Neurophysiology,SchoolofLifeScience

EastChinaNormalUniversity,Shanghai,China

1996-2000,Bachelor

Biology,DepartmentofBiology

EastChinaNormalUniversity,Shanghai,China

ResearchandWorkingExperience:

2012/03-presentFIST

Xi’anJiaotongUniversity

2007/12-2012/03Post-doctoralFellow(Prof.MinZhuo)

DepartmentofPhysiology

UniversityofToronto

2006/5–2007/10Visitingstudent(Prof.ShuminDuan)

LabofSynapseDevelopment&Plasticity

InstituteofNeuroscience

2002/9–2007/6GraduateStudent(Prof.Xin-DeSun)

SchoolofLifeScience.

Researchcenterforbrainscience,

EastChinaNormalUniversity,Shanghai,China

2000/7-2002/8AssistantTeacher

BiologyDepartment

NanyangTeacher’sCollege,Henan,China

1999/12–2000/6VisitingStudent

LabofBiophysics(Prof.ZhuanZhou)

InstituteofNeuroscience

ChineseAcademyofSciences,China

Fellowship:

2010/4-2012/04Post-doctoralfellowshipfromCIHR&

FragileXresearchfoundationofCanada

Researchinterests

1.Thetemporalprocessingofinformationincentralnervoussystem.

Thecentralnervoussystemisoneofthemostimportantpartsofhuman.Theneuronsincentralnervoussystemprocessinformationfromperipheralnervoussystem.Thetemporalpropertiesofspikescarrycriticalinformation,whichhasbeenfoundtobeinvolvedinthebrainfunctionundernormalanddiseasecondition.Mygroupwillcombinedifferentapproachtoinvestigatehowthetemporalsummationofinformationcodingisinvolvedinthebrainfunction.

2.Theenergymetabolismofcentralnervoussystemunderchronicpaincondition.

Humanbrainimagingresultssuggestthattheenergymetabolismofpainrelatedareaswaschangedunderchronicpaincondition.However,thecellularandmolecularmechanismmediatingthischangekeptunclear.Energymetabolismhasbeenprovedtobeinvolvedinthemaintenanceoflong-termmemory,whichshedalightthattheenergymetabolismisimportantforthemaintenanceofchronicpain,wethereforeplantocombinedifferentapproachestoinvestigatetherelatedmechanismmediatingthechangeofenergymetabolismunderchronicpaincondition.

Researcharticlesandreviews

1.LiXY,ChenT,DescalziG,KogaK,QiuS,ZhuoM.CharacterizationofneuronalintrinsicpropertiesandsynaptictransmissioninlayerIofanteriorcingulatecortexfromadultmice,MolecularPain.20128:53.

2.DescalziG,LiXY,ChenT,KogaK,MercaldoV,KbbngH,ZhuoM.Rapidalterationswithintheanteriorcingulatecortexmediatetracefearlearning.MolecularBrain.20125:6.

3.SteenlandH,LiXY,ZhuoM.,PredictingAversiveEventsandTerminatingFearintheMouseAnteriorCingulateCortexduringTraceFearConditioning.J.Neurosci.201232,(3):1082

4.AbumariaN,YinB,ZhangL,LiXY,ChenT,DescalziG,ZhaoL,AhnM,LuoL,RanC,ZhuoM,LiuG.Effectsofelevationofbrainmagnesiumonfearconditioning,fearextinction,andsynapticplasticityintheinfralimbicprefrontalcortexandlateralamygdala.J.Neurosci.2011,31(42):14871-81.

5.ToyadaH*,LiXY*,WuLJ,ZhaoMG,DescalziG,ChenT,KogaK,ZhuoM.Interplayofamygdalaandcingulateplasticityinemotionalfear.NeuralPlasticity.2011,2011:813749.(*Equalcontributor).

6.KogaK*,ChenT*,LiXY*,DescalziG,LingJ,GuJ,ZhuoM.GlutamateactsasaneurotransmitterforGRP-relateditchinmammalianspinalcord.MolecularPain,7:47.(*Equalcontributor).

7.QiuS,LiXY,ZhuoM.PosttranslationalmodificationofNMDAreceptorGluN2Bsubunitanditsrolesinpainandmemory.SeminarsinCellandDevelopmentalBiology,2011,22(5):521-9.(review)

8.LiXY,KoHY,ChenT,CollingridgeGL,KbbngBK,ZhuoM.Erasinginjury-relatedcorticalsynapticpotentiationasanewtreatmentforchronicpain.JournalofMolecularMedicine.2011,89(9):847-55(review).

9.KimSS*,WangH*,LiXY*,ChenT*,MercaldoV,DescalziG,WuLJ,ZhuoM.Neurabinintheanteriorcingulatecortexregulatesanxiety-likebehaviorinadultmice.MolecularBrain.2011,4:6.(*Equalcontributor).

10.LiXY*,KoHG*,ChenT*,DescalziG,KogaK,WangH,KimSS,ShangY,KwakC,ParkSW,ShimJ,LeeK,CollingridgeGL,KbbngBK,ZhuoM.AlleviatingneuropathicpainhypersensitivitybyinhibitingPKMzetaintheanteriorcingulatecortex.Science.2010;330(6009):1400-4.(*Equalcontributor,SciencesignalingEditor’schoice,Naturehighlighted,F1000highlighted)

11.ChenT,KogaK,LiXY,ZhuoM.Spinalmicroglialmotilityisindependentofneuronalactivityandplasticityinadultmice.MolecularPain.2010;6:19.

12.WuLJ,MellströmB,WangH,RenM,DomingoS,KimSS,LiXY,ChenT,NaranjoJR,ZhuoM.DREAM(DownstreamRegulatoryElementAntagonistModulator)contributestosynapticdepressionandcontextualfearmemory.MolecularBrain.2010;3:3.

13.KogaK,LiXY,ChenT,SteenlandHW,DescalziG,ZhuoM.Invivowhole-cellpatch-clamprecordingofsensorysynapticresponsesofcingulatepyramidalneuronstonoxiousmechanicalstimuliinadultmice.MolecularPain.2010;6:62.

14.CaoXY,XuH,WuLJ,LiXY,ChenT,ZhuoM.Characterizationofintrinsicpropertiesofcingulatepyramidalneuronsinadultmiceafternerveinjury.MolecularPain.2009;5:73

15.WuLJ,LiXY,ChenT,RenM,ZhuoM.Characterizationofintracorticalsynapticconnectionsinthemouseanteriorcingulatecortexusingdualpatchclamprecording.MolecularBrain.2009;2:32.

16.TongXP,LiXY,ZhouB.ShenW.ZhangZJ.XuTL.DuanS.Ca2+signalingevokedbyactivationofNa+channelsandNa+/Ca2+exchangersisrequiredforGABA-inducedNG2cellmigration.J.CellBiol.2009,186(1):113-128.

17.VecseyCG.BaillieG.JaganathD.HavekesR.DanielsA.WimmerM.HuangT.BrownK.LiXY.DescalziG.KimSS.ChenT.ShangYZ.ZhuoM.HouslayMD.AbelT.SleepdeprivationimpairscAMPsignalinginthehippocampus.2009.Nature.2009;461(7267):1122-5

18.WuLJ*,KimSS*,LiXY*,ZhangF*,ZhuoMin.Sexualattractionenhancesglutamatetransmissioninmammaliananteriorcingulatecortex.MolecularBrain,2009;1:9.(*Equalcontributor)

19.ShangY,WangH,MercaldoV,LiXY,ChenT,ZhuoM.FragileXmentalretardationproteinisrequiredforchemically-inducedlong-termpotentiationofthehippocampusinadultmice.J.Neurochem.2009,111(3):635-46

20.LiaoCY,LiXY,WuB,DuanS.JiangGBAcuteenhancementofsynaptictransmissionandchronicinhibitionofsynaptogenesisinducedbyperfluorooctanesulfonatethroughmediationofvoltage-dependentcalciumchannel.Environ.Sci.Technol.2008,42(14):5335-41.

21.LiXY,LiL,ZhangJP,SunXD.Thebehavioralpresentationsofaudio-visualintegrationinrats.Academicjournalofsecondmilitarymedicaluniversity,2007,28(5):480-483.

22.LiXY,GaoF,ZhangZ,ZhangJP,SunXD.Auditorycuesinducedtheplacenavigationinrats.JournalofFudanuniversity(naturalscienceedition),2007,46(6).

23.GaoF.ChenL.PuQ.LiXY.SunXD.ZhangJP.InfluenceofPrenatalNoiseExposureontheAuditoryObjectExplorationBehaviorofAdultRats.ChineseJournalofZoology,2007,42(5):20-26.

24.WangXY,YuLP,LiXY,ZhangJP,SunXD.Auditory-visualMultisensoryNeuronsandAuditory-visualInformationIntegrationinNewbornRatCortex.ChineseJournalofZoology,2006,41(4):31-40.

25.YuLP,WangXY,LiXY,ZhangJP,SunXD.TheAuditory-visualMultisensoryNeuronsandAuditory-visualInformationIntegrationinRatCortex.ProgressinBiochemistryandBiophysics,2006,33(7):677-684.