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姓名何正国性别男
职称“长江学者 ”特聘教授学位博士
电话02787284300邮箱hezhengguo@mail.hzau.edu.cn
工作单位生命科学技术学院，农业微生物学国家重点实验室
研究方向结核分枝杆菌的基因网络、耐药机制以及抗结核药物靶标
教育经历1988-1992华中农业大学土化系微生物学专业 ，学士
1992-1995华中农业大学土化系微生物学专业 ，硕士
1998-2001中国科学院微生物研究所微生物学专业，博士
主要职历2001.8-2004.7美国哈佛大学医学院生物化学与分子药物系，博士后
2004.9-2005.8湖北大学生命科学学院 ，特聘教授
2005.9-今华中农业大学生命科学技术学院 ，教授 、博士生导师
科研成果结核分枝杆菌是一种重要的病原细菌，能感染人和多种动物引起结核病 ，对人类健康和公共卫生安全构成了严重威胁。我国是结核病的重灾区 ，患者人数居世界第二位，每年死亡人数多达15万 。特别是 ，对于耐药型结核目前几乎无药可治 ，亟待研发新型药物和防控技术 。为此，本团队主要通过构建和解析该重要病原细菌的基因调控网络 ，阐明其生长和耐药调控机制 ，发现新功能基因和新药靶，最终研发具有自主知识产权的诊断产品和新型疫苗。代表性论文（*为通讯作者）(1)ManmanGuo,HuiFeng,JunZhang,WenqinWang,YiWang,YuqingLi,ChunhuiGao,HuanchunChen,YingFeng,Zheng-GuoHe*.Dissectingtranscriptionregulatorypathwaysthroughanewbacterialone-hybridreportersystem.GenomeRes.19(7):1301-1308(2009)(2)LuZhang,LeiZhang,YiLiu,ShifanYang,ChunhuiGao,HongchaoGong,YingFeng,Zheng-GuoHe*.Archaealeukaryote-likeOrc1/Cdc6initiatorsphysicallyinteractwithDNApolymeraseB1andregulateitsfunctions.ProcNatlAcadSciUSA.106(19):7792-7797(2009).(3)FengHuang,Zheng-GuoHe*.CharacterizationofaninterplaybetweenaMycobacteriumtuberculosisMazFhomolog,Rv1495,anditssoleDNAtopoisomeraseI.NucleicAcidsRes.38(22):8219-8230(2010)(4)MinYang,ChunhuiGao,TaoCui,JingningAn,Zheng-GuoHe*.ATetR-likeregulatorbroadlyaffectstheexpressionsofdiversegenesinMycobacteriumsmegmatis.NucleicAcidsRes.40(3):1009-1020(2012)(5)WeihuiLi,Zheng-GuoHe*.LtmA,anovelcyclicdi-GMPresponsiveactivator,broadlyregulatestheexpressionoflipidtransportandmetabolismgenesinMycobacteriumsmegmatis.NucleicAcidsRes.40(22):11292-307(2012).(6)YuqingLi,JumeiZeng,JianfangShi,MingchaoWang,MudingRao,ChaolunXue,YanliDu,Zheng-GuoHe*.Aproteome-scaleidentificationofnovelantigenicproteinsinMycobacteriumtuberculosistowardsdiagnosticandvaccinedevelopment.JProteomeRes.9(9):4812-4822(2010)(7)YiWang,TaoCui,CongZhang,MinYang,YuanxiaHuang,WeihuiLi,LeiZhang,ChunhuiGao,YangHe,YuqingLi,FengHuang,JumeiZeng,ChengHuang,QiongYang,YuxiTian,ChunchaoZhao,HuanchunChen,HuaZhang,Zheng-GuoHe*.Globalprotein-proteininteractionnetworkinthehumanpathogenMycobacteriumtuberculosisH37Rv.JProteomeRes.9(12):6665-6677(2010).(8)JumeiZeng,TaoCui,Zheng-GuoHe*.AGenome-wideRegulator-DNAInteractionNetworkinthehumanpathogenMycobacteriumtuberculosisH37Rv.JProteomeRes.11(9):4682-4692(2012)(9)YiWang,YuanxiaHuang,ChaolunXue,YangHe,Zheng-GuoHe*.AClpR-likeregulatorspecificallyrecognizesaRecA-independentpromotermotifandbroadlyregulatesexpressionofDNAdamageinduciblegenesinmycobacteria.JBiolChem.286(36):31159-31167(2011).(10)MudingRao,HuicongLiu,MinYang,Chunchaozhao,Zheng-GuoHe*.Acopper-responsiveglobalrepressorregulatesexpressionofdiversemembrane-associatedtransportersandbacterialdrugresistanceinmycobacteria.JBiolChem.287(47):39271-39371(2012)(11)ShifanYang,ZengqiangGao,TingtingLi,MinYang,TianyiZhang,YuhuiDong*,Zheng-GuoHe*.StructuralbasisforinteractionbetweenM.smegmatisMs6564,aTetRfamilymasterregulator,anditstargetDNA.JBiolChem.288(33):23687-95(2013).(12)LeiZhang,Zheng-GuoHe*.Radiation-sensitivegeneA(RadA)targetsDisA,DNAintegrityscanningproteinA,tonegativelyaffectitscyclic-di-AMPsynthesisactivityinMycobacteriumsmegmatisJBiolChem.288(31):22426-22436(2013).(13)LeiZhang,WeihuiLi,Zheng-GuoHe*.DarR,aTetR-liketranscriptionalfactor,isacyclic-di-AMPresponsiverepressorinMycobacteriumsmegmatis.JBiolChem.288(5):3085-3096(2013).(14)LeiLiu,ChengHuang,Zheng-GuoHe*.ATetR-familytranscriptionalfactordirectlyregulatestheexpressionofa3-methyladenineDNAglycosylaseandphysicallyinteractswiththeenzymetostimulateitsbaseexcisionactivityinMycobacteriumbovisBCG.JBiolChem.289(13):9065-9075(2014)(15)BinWang,ShifanYang,LeiZhang,Zheng-GuoHe*.Archaealeukaryote-likeserine/threonineproteinkinaseinteractswithandphosphorylatesaforkhead-associateddomain-containingprotein.JBacteriol.192(7):1956-1964(2010).(16)TaoCui,LeiZhang,XizhouWang,Zheng-GuoHe*.UncoveringnewsignalingproteinsandpotentialdrugtargetsthroughtheinteractomeanalysisofMycobacteriumtuberculosis.BMCGenomics,10(1):118(2009)(17)HuaZhang,ZhuanmeiZhang,JianYang,Zheng-GuoHe*.FunctionalcharacterizationofDnaBhelicaseanditsmodulationbysingle-strandedDNA-bindingproteininMycobacteriumtuberculosis.FEBSJ.281:1256-1266(2014).(18)MinYang,ChunhuiGao,YiWang,HuaZhang,Zheng-GuoHe*.Characterizationoftheinteractionandcross-regulationofthreeMycobacteriumtuberculosisRelBEmodules.PLoSONE.5(5):e10672(2010)(19)FengHuang,Zheng-GuoHe*.CharacterizationofaConservedInteractionbetweenDNAGlycosylaseandParAinMycobacteriumsmegmatisandM.tuberculosis.PLoSONE7(6):e38276(2012).(20)ChunhuiGao,MinYang,Zheng-GuoHe*.CharacterizationofanovelArsR-likeregulatorencodedbyRv2034inMycobacteriumtuberculosis.PLoSONE7(4):e36255(2012).(21)YuqingLi,Zheng-GuoHe*.ThemycobacterialLysR-typeregulatorOxySrespondstooxidativestressandnegativelyregulatesexpressionofthecatalase-peroxidasegene.PLoSONE7(1):e30186(2012).
备注先后获国家杰出青年科学基金 、教育部“长江学者 ”特聘教授、科技部“中青年科技创新领军人才”、全国优秀科技工作者 、全国农业科研杰出人才 、国务院政府特殊津贴、湖北省高端引领性人才 、湖北省“楚天学者”特聘教授等荣誉或奖励。牵头组建的团队入选湖北省自然科学基金创新群体,指导的研究生4次在湖北省和全国大学生“挑战杯 ”赛中获奖（其中包括特等奖1项） 。
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