导师信息#兰州大学生命科学学院导师介绍#何永兴

学习经历

2011/02-2013/02，加州大学伯克利分校 ，生物物理系
，博士后

2005/09-2010/12，中国科大 ，生化与分子生物系
，博士

2001/09-2005/07，中国科大 ，生命科学院
，学士
。

工作经历

2013/03-今，兰州大学引进人才 ，副教授。

教学及指导研究生情况主讲本科生必修课《生物信息学》
，选修课《生物大分子的结构与功能》 。

发表论文及专著

1:MuY,LianFM,TengYB,AoJ,JiangYL,HeYX,ChenY,ZhouCZ,ChenX.The
N-terminalβ-sheetofperoxiredoxin4inthelargeyellowcroakerPseudosciaena
croceaisinvolvedinitsbiologicalfunctions.PLoSOne.2013;8(2):e57061.

2:HeYX,ZhangNN,LiWF,JiaN,ChenBY,ZhouK,ZhangJ,ChenY,ZhouCZ.
N-TerminaldomainofBombyxmorifibroinmediatestheassemblyofsilkin
responsetopHdecrease.JMolBiol.2012May4;418(3-4):197-207.

3:KangY,HeYX,ZhaoMX,LiWF.StructuresofnativeandFe-substitutedSOD2
fromSaccharomycescerevisiae.ActaCrystallogrSectFStructBiolCrystCommun.
2011Oct1;67(Pt10):1173-8.

4:YangJP,MaXX,HeYX,LiWF,KangY,BaoR,ChenY,ZhouCZ.Crystal
structureofthe30KproteinfromthesilkwormBombyxmorirevealsanewmember
oftheβ-trefoilsuperfamily.JStructBiol.2011Jul;175(1):97-103.

5:DuY,ShiWW,HeYX,YangYH,ZhouCZ,ChenY.Structuresofthe
substrate-bindingproteinprovideinsightsintothemultiplecompatiblesolute
bindingspecificitiesoftheBacillussubtilisABCtransporterOpuC.BiochemJ.
2011Jun1;436(2):283-9.

6:DuY*,HeYX*,ZhangZY,YangYH,ShiWW,FroletC,DiGuilmiAM,VernetT,Zhou
CZ,ChenY.Crystalstructureofthemucin-bindingdomainofSpr1345from
Streptococcuspneumoniae.JStructBiol.2011Apr;174(1):252-7.
7:MaG,YuJ,XiaoY,ChanD,GaoB,HuJ,HeY,GuoS,ZhouJ,ZhangL,GaoL,
ZhangW,KangY,CheahKS,FengG,GuoX,WangY,ZhouCZ,HeL.Indianhedgehog
mutationscausingbrachydactylytypeA1impairHedgehogsignaltransductionat
multiplelevels.CellRes.2011Sep;21(9):1343-57.8:ZhangX,TengYB,LiuJP,HeYX,ZhouK,ChenY,ZhouCZ.Structuralinsightsintothecatalyticmechanismoftheyeastpyridoxal5-phosphatesynthaseSnz1.BiochemJ.2010Dec15;432(3):445-50.

9:ZhaoMX,JiangYL,HeYX,ChenYF,TengYB,ChenY,ZhangCC,ZhouCZ.StructuralbasisfortheallostericcontroloftheglobaltranscriptionfactorNtcAbythenitrogenstarvationsignal2-oxoglutarate.ProcNatlAcadSciUSA.2010Jul13;107(28):12487-92.

10:DuY,HeYX,GaowaS,ZhangX,ChenY,ZhangSC,ZhouCZ.CrystalstructuresoftheapoandGDP-boundformsofacupin-likeproteinBbDUF985fromBranchiostomabelcheritsingtauense.Proteins.2010Sep;78(12):2714-9.

11:LuoM,JiangYL,MaXX,TangYJ,HeYX,YuJ,ZhangRG,ChenY,ZhouCZ.StructuralandbiochemicalcharacterizationofyeastmonothiolglutaredoxinGrx6.JMolBiol.2010May14;398(4):614-22.

12:ZhangNN,HeYX,LiWF,TengYB,YuJ,ChenY,ZhouCZ.CrystalstructuresofholoandCu-deficientCu/Zn-SODfromthesilkwormBombyxmoriandtheimplicationsinamyotrophiclateralsclerosis.Proteins.2010Jun;78(8):1999-2004.

13:HeYX,HuangL,XueY,FeiX,TengYB,Rubin-PitelSB,ZhaoH,ZhouCZ.Crystalstructureandcomputationalanalysesprovideinsightsintothecatalyticmechanismof2,4-diacetylphloroglucinolhydrolasePhlGfromPseudomonasfluorescens.JBiolChem.2010Feb12;285(7):4603-11.

14:TengYB,JiangYL,HeYX,HeWW,LianFM,ChenY,ZhouCZ.StructuralinsightsintothesubstratetunnelofSaccharomycescerevisiaecarbonicanhydraseNce103.BMCStructBiol.2009Oct24;9:67.

15:MaXX,JiangYL,HeYX,BaoR,ChenY,ZhouCZ.Structuresofyeastglutathione-S-transferaseGtt2revealanewcatalytictypeofGSTfamily.EMBORep.2009Dec;10(12):1320-6.

16:TengYB,MaXX,HeYX,JiangYL,DuJ,XiangC,ChenY,ZhouCZ.CrystalstructureofArabidopsistranslationinitiationfactoreIF-5A2.Proteins.2009Nov15;77(3):736-40.

17:WangY,HeYX,YuJ,ZhouCZ.Cloning,overproduction,purification,crystallizationandpreliminaryX-raydiffractionanalysisofyeastglutaredoxinGrx5.ActaCrystallogrSectFStructBiolCrystCommun.2009Jun1;65(Pt6):651-3.

18:HeYX,GuiL,LiuYZ,DuY,ZhouY,LiP,ZhouCZ.CrystalstructureofSaccharomycescerevisiaeglutaminesynthetaseGln1suggestsananotube-likesupramolecularassembly.Proteins.2009Jul;76(1):249-54.

19:HuangL,SunF,LiangC,HeYX,BaoR,LiuL,ZhouCZ.CrystalstructureofLZ-8fromthemedicinalfungusGanodermalucidium.Proteins.2009May1;75(2):524-7.doi:10.1002/prot.22346.

20:ZhangWJ*,HeYX*,YangZ,YuJ,ChenY,ZhouCZ.Crystalstructureofglutathione-dependentphospholipidperoxidaseHyr1fromtheyeastSaccharomycescerevisiae.Proteins.2008Dec;73(4):1058-62.

21:WangS,HeYX,BaoR,TengYB,YeBP,ZhouCZ.Cloning,expression,purification,crystallizationandpreliminaryX-raydiffractionanalysisofhypotheticalproteinSCO4226fromStreptomycescoelicolorA3(2).ActaCrystallogrSectFStructBiolCrystCommun.2008Sep1;64(Pt9):847-50.

参与翻译编写《英汉生物技术词典》，化学工业出版社 ，2009.