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导师信息#兰州大学生命科学学院导师介绍#丁伟

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学习经历

◆2001.9-2005.6兰州大学生命科学院生物学国家基地班学士
◆2005.9-2010.6兰州大学和中科院上海有机化学研究所联合陪养化学生物学博士

工作经历

◆2010.9-2012.5德国sbbrland大学和Helmholtz研究所抗感染sbbr中心药物生物技术博士后
◆2013.1至今兰州大学生命科学院微生物所副教授

教学及指导研究生情况

指导研究生2名

发表论文及专著

1.InsightintoBacterial6-MethylsalicyclicAcidSynthaseandItsEngineeringtoOrsellinicAcidSynthaseforNovelSpirotetronatesGeneration.
WeiDing,ChunLei,QingliHe,YurongBi,WenLiu.
Chemistry&Biology,2010,17,495–503(IF=6.5)
2.Biosynthesisof3-Methoxy-5-MethylNaphthoicAcidandItsIncorporationintotheAntitumorantibioticAzinomycinB.
WeiDing,WeiDeng,ManchenTang,GongliTang,YurongBi,WenLiu.
MolecularBioSystems,2010,6,1071-1081(IF=4.5)
3.Nitricoxidemediatesabscisicacidinducedthermotoleranceinthecalluses
fromtwoecotypesofreedunderheatstress.
LiliSong,WeiDing,JuanShen,ZhiguoZhang,YurongBi,LixinZhang.
PlantScience,2008,175(6):826-832.(Co-firstauthor)(IF=2.5)
4.EffectofabscisicacidonheatstresstoleranceinthecallifromtwoecotypesofPhragmitescommunis
WeiDing,LiliSong,YurongBi.
BiologiaPlantarum,2010,54(1–4):607-613(IF=1.97)
5.GeneticcharacterizationoftheSaframycinAgeneclusterfromStreptomyceslavendulaeNRRL11002revealingaNRPSsystemforthecharacteristicbisquinonebiosynthesisinaniterativemanner.
LeiLi,WeiDeng,JieSong,WeiDing,Qunfei,Zhao,WeiwenSong,GongliTang,WenLiu.
JournalofBacteriol,2008,290,251–263.
6.CharacterizationoftheAzinomycinBBiosyntheticGeneClusterRevealingaDifferentIterativeTypeIPolyketideSynthaseforNaphthoateBiosynthesis.
QunfeiZhao,QingliHe,WeiDing,ManchengTang,QianjinKang,YiYu,WeiDeng,QiZhang,JieFang,GongliTang,andWenLiu.
Chemistry&Biology,2008,15,693-705.
7.AromaticpolyketidesproducedbybacterialIterativetypeIpolyketidesynthases
QiZhang,BoPang,WeiDing,andLiu,Wen*
ACSCatal.,2013,3(7),pp1439–1447
8.Nitricoxideprotectsagainstoxidativestressunderheatstressinthecallusesfromtwoecotypesofreed.
LiliSong,WeiDing,MinguiZhao,BaotengSun,LixinZhang.
PlantScience,2006,171(4):449-458.
9.Engineer6-MSASandCombinatorialsynthesisNewSpirotrtronatesantibioticswithimprovedbioactivity
WenLiu,weiding
(ChinesepatentNo.:200910247567.8)

研究方向

微生物天然产物(抗生素)的宏基因组发掘(genomemining),重要生物活性抗生素的生物合成机制和新型酶催化反应机制研究 ,重要临床药物中间体的生物转化,抗生素工业菌种的基因工程改造 。

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