导师信息#兰州大学基础医学院导师介绍#李文广

姓名:李文广
Name:LiWenguang
职务：教授
Duty:Professor
E-mail：wenguangli2003@yahoo.com.cn

一、科研方向

抗肿瘤药理学。
新药临床前药理学 。
ResearchInterests：
AntitumorPharmacology。
PreclinicalPharmacologyofNewDrugs
。

二 、荣誉称号及奖励：

2002年获第九届甘肃省青年教师成材奖。
《葡萄籽中原花青素对阿霉素增效减毒作用及机理研究》获2006年甘肃省高校科技进步一等奖（2/8） 。
honorsandawards：
2002obtainedTheninthYoungTeachersChengcaiAwardinGansuProvince
。
2006MechanismsofProanthocyanidinfromGrapeSeedsinbothPotentiatingAnti-tumorActivityandReducingToxicityofDoxorubicinobtainedthesecondprizeofGansuProvincialNaturalScience.(secondauthor)。

三、个人简历

教育背景：
1983年9月至1988年7月在原兰州医学院临床医学系攻读本科
1988年9月至1991年7月在原兰州医学院药理学攻读硕士
2003年9月至2006年6月在兰大生命科学学院攻读博士
工作经历：
1991年7月至1994年7月兰州医学院药理学教研室助教
1994年7月至1998年7月兰州医学院药理学教研室讲师
1998年7月至2003年12月兰州医学院药理学教研室副教授
2003年12月至2004年11月兰州医学院药理学教研室教授
2004年11月至今兰州大学药学院药理学教研室教授
Resume：
Education：
Sept.2003至June2006Ph.D.intheLifeScienceSchoolofLanzhouUniversity,Lanzhou730000,Gansu,P.R.China
Sept.1988至June1991M.S.inPharmacology,theDepartmentofPharmacologyofLanzhouMedicalCollege,Lanzhou730000,Gansu,P.R.China
Sept.1983至July1988B.S.inClinicalMedicine,theDepartmentofClinicalMedicineofLanzhouMedicalCollege,Lanzhou730000,Gansu,P.R.China
WorkingExperiences：
Nov.2004至NowProfessor,InstituteofPharmacology ，SchoolofBasicMedicineScience,LanzhouUniversity,Lanzhou730000,Gansu,P.R.China
Dec.2003至Nov.2004Professor,DepartmentofPharmacology，LanzhouMedicalCollege,Lanzhou730000,Gansu,P.R.China
July.1998至Dec.2003AssociateProfessor,DepartmentofPharmacology,LanzhouMedicalCollege,Lanzhou730000,Gansu,P.R.China
July.1994至July.1998Lecturer,DepartmentofPharmacology,LanzhouMedicalCollege,Lanzhou730000,Gansu,P.R.China
July1991至July.1994Assistant
，DepartmentofPharmacology,LanzhouMedicalCollege,Lanzhou730000,Gansu,P.R.China

四
、发表论文（按年度）

LIWenguang,ZHANGXiaoYu,WUYongJieandTIANXuan.Anti-inflammatoryeffectandmechanismofproanthocyanidinsfromgrapeseeds.ActaPharmacol.Sin.2001;22(12):1117-1120.(SCI) 。
LIWenguang,ZHANGXiaoYu,WUYongJieandTIANXuan.Antioxidativeactivityofspinlabelledderivativesofpodophyllilicacidhydrazide.ActaPharmacol.Sin.2002;23(8):727?732.(SCI)
WenGuangLI,XiaoYuZHANG,YongJieWU,MingTangGAOandRongliangZHENG..Therelationshipbetweenstructureandantioxidativeactivityofpiperidinenitroxides.J.Pharm.Pharmacol.2006;58(7):941?949.(SCI)
TuanmingYANG,ShiFangGUO,ChangruiCHENG,XiaoYuZHANGandWenguangLI.Anti-osteosarcomaeffectsandmechanismsof4-O-amino-phenol-4′-demethylepipodophyllotoxinether.J.Pharm.Pharmacol.2008；60(2):179-188.(SCI)
WUYong-jie,LIWen-guang,ZHANGZhen-mingandTIANXuan.Antioxidativeactivityof4-oxyand4-hydroxynitroxidesintissuesanderythrocytesfromrats.ctaPharmacologicaSinica.1997;18(6):510-514
XiaoYuZHANG,WenGuangLI,YongJieWU,TianZhenZHENG,WeiLI,SongYiQUandNaiFaLIU.Proanthocyanidinfromgrapeseedspotentiatesanti-tumoractivityofdoxorubicinviaimmunomodulatorymechanism.Int.Immunopharmacol.2005;5(7-8):1247?1257.(SCI)
XiaoYuZHANG,WenGuangLI,YongJieWU,DeChengBAI,andNaiFaLIU.Proanthocyanidinfromgrapeseedsenhancesdoxorubicin-inducedanti-tumoreffectandreversesdrugresistanceindoxorubicin-resistantK562/DOXcells.Can.J.Physiol.Pharmacol.2005;83(3):309?318.(SCI)
XiaoYuZHANG,WenGuangLI,YongJieWUandMingTangGAO.Ameliorationofdoxorubicin-inducedmyocardialoxidativestressandimmunosuppressionbygrapeseedproanthocyanidinsintumor-bearingmice.J.PharmacyPharmacol.2005:57(8):1043?1052.(SCI)
XiaoYuZHANG,WenGuangLI,YongJieWUandXuanTIAN.Antioxidativeandantitumoractivityofspinlabeledderivativesof4-β-amino-4'-demethylepipodophyllotoxinandtheirstructure-activityrelationship.Pharmazie.2007;62(6):432?438.(SCI)
TIANXuan,ZHANGFu-minandLIWen-guang.Antitumorandantioxidantactivityofspinlabeledderivativesofpodophyllotoxin(GP-1)andcongener.LifeSciences.2002;70:2433-2443
WANGJun-zhi,BAIDe-cheng,RAOChun-ming,LIWen-guang,GAOMing-tang,WANGXiao-qiandWUYong-jie.Effectsof2.5smousenervegrowthfactoronregenerationofinjuredsciaticnervesinmiceandrats.ActaPharmacologicaSinica.1997;18(6):501-504
ZHANGYi,WANGJun-zhi,WUYong-jieandLIWen-guang.Anti-inflammatoryeffectofrecombinanthumansuperoxidedismutaseinratsandmiceanditsmechanism.ActaPharmacologicaSinica.2002;23(5):439-444
XUEXiao-chang,WUYong-jie,GAOMing-tang,LIWen-guang,ZHAONing,WANGZen-glu,BAOChun-jie,YANZhenandZHANGYing-qi.ProtectiveeffectsofpentadecapeptideBPC157ongastriculcerinrats.WorldJ.Gastroenterol.2004;10(7):1032-1036
XiaoyuZHANG,DechengBAI,YongjieWU,WenguangLIandNaifaLIU.Proanthocyanidinfromgrapeseedsenhancesanti-tumoreffectofdoxorubicinbothinvitroandinvivo.Pharmazie.2005;60(7):533?538.(SCI)
WANGJun-zhi,WUYong-jie,RAOChun-ming,GAOMing-tangandLIWen-guang.Effectofrecombinanthumanbasicfibroblastgrowthfactoronstomachulcersinratsandmice.ActaPharmacologicaSinica.1999;20(8):763-768
ZHANGXiaoYu,LIWenGuang,ZHENGTianZhenandLI　Wei.Effectsofproanthocyanidinsoncontractileactivityofaorticsmoothmuscleandplateletaggregationinexperimentalanimals.ChinJApplPhysiol.2005;21(4):383-386.(CSCD)
ZHANGXiaoYu,LIWenGuang,GAOMingTangandTIANXuan.Protectectiveeffectoninjuredmyocardialcellsofproanthocyanidinsinvitro.PharmacolClinChinMateriaMed.2001;17(6):14-16.(CSCD)
ZHANGXiaoYu,GAOMingTang,LIWenGuang,TIANXuanandZHUJuHua.Theanti-lipoperoxidativeeffectofgrapeseedextractinvitro.AdvancedinFreeBadicalLifeSciences.1999;7:116-120.
ZHANGXiaoYu,ZHANGYongPingandLIWenGuang.Anti-tumoractivityoflanthanumnitrateComplexeswithbis(2-pyridyl-N-Oxide)disulphideinvitro.J.LanzhouUniversity(NaturalSci).2004;40Supp:34?36..(CSCD)
ZHANGXiaoYu,LIWenGuang,WUYongJieandGAOMingTang.CHLchromosomeaberrationtestofproanthocyanidinsfromgrapeseeds.JLanzhouUniversity(NaturalSci).2002;38(6)Supp:15-17..(CSCD)
LIWenGuang,ZHANGXiaoYuandWUYongJie.EffectofpodophyllicacidhydrozidepiperidingyloxyanditsderivativesonMDAformation.ChinPharmacolBull.1997;13(5):422-424..(CSCD)

五、学术团队

在校：吴勇杰高明堂李文广覃红张坚崔明霞路莉张宝来王莉