导师信息#兰州大学药学院导师介绍#王少华

姓名：王少华(男)
职称职务：副教授
电子邮箱：wangshh@lzu.edu.cn

学习与工作经历

1997年9月-2001年6月兰州大学 ，化学化工学院化学专业
，获学士学位；
2001年9月-2006年6月兰州大学，化学化工学院有机化学专业 ，博士学位，导师：涂永强院士
2006年7月-2011年8月MayoClinic
，DepartmentofMolecularPharmacology&ExperimentalTherapeutics，高级研究助理
2011年8月-今兰州大学 ，药学院
，副教授

教学工作与成果

负责本科生《分析化学》和研究生《专业外语》的教学工作。

科研项目与成果

1.Yong-QiangZhang,Dao-YongZhu,Bao-ShengLi,Yong-QiangTu,*Ji-XingLiu,YongLu，Shao-HuaWang*
Palladium-CatalyzedCascadeProcesstoConstruct2,5-DisubstitutedPyrroles
Submitted
2.Yuan-PingPang,*J.G.Park,Shao-HuaWang,A.Vummenthala,R.K.Mishra,J.E.McLaughlin,R.Di,J.N.Kahn,N.E.Tumer,L.Janosi,J.Davis,C.B.Millard.
SmallMoleculeInhibitorLeadsofRibosome-InactivatingProteinsDevelopedUsingtheDoor-stopApproach.
PLoSONE,2011,6,e17883.
3.Yuan-PingPang,*J.Davis,*Shao-HuaWang,J.G.Park,M.P.Nambiar,JamesJ.Schmidt,C.B.Millard.
SmallMoleculesShowingSignificantProtectionofMiceagainstBotulinumNeurotoxinSerotypeA.
PLoSONE,2010,5,e10129.
4.Yuan-PingPang,*A.Vummenthala,R.K.Mishra,J.G.Park,Shao-HuaWang,J.Davis,C.B.Millard,JamesJ.Schmidt.
PotentNewSmall-MoleculeInhibitorofBotulinumNeurotoxinSerotypeAEndopeptidaseDevelopedbySynthesis-BasedComputer-AidedMolecularDesign.
PLoSONE,2009,4,e7730.
5.Jian-DongLiu,Shao-HuaWang,Fu-MinZhang,Yong-QiangTu,*Yong-QiangZhang.
ConciseTotalSynthesisof(±)-Crinine.
Synlett,2009,12,3040-3042.
6.Fu-MinZhang,Yong-QiangTu,*Jian-DongLiu,Xiao-HuiFan,LeiShi,Xiang-DongHu,Shao-HuaWang,Yong-QiangZhang.
Ageneralapproachtocrinine-typeAmaryllidaceaealkaloids:totalsynthesesof(±)-haemanthidine,(±)-pretazettine,(±)-tazettine,and(±)-crinamine.
Tetrahedron,2006,62,9446-9455.
7.Shao-HuaWang,Yong-QiangTu,*MinWang.
t-BuOKpromotedcouplingofalkynesandaldehydes:aconcisesyntheticmethodofbeta,gamma-unsaturatedenones.
TetrahedronLett.,2006,47,8621-8623.
8.Shao-HuaWang,Yong-QiangTu,*PenChen,Xiang-DongHu,Fu-MinZhang,Ai-XiaWang.
KOtBu-promotedthree-componentcouplingofaldehydesandalkynes:Highlyefficientsynthesisof1-En-4-yn-3-olsand2-En-4-yn-1-ols.
J.Org.Chem.,2006,71,4343-4345.
9.Shao-HuaWang,Yong-QiangTu,*PenChen.
Enantioselectiveadditionofphenylacetylenetoketonescatalyzedbytitanium(IV)complexesofN-sulfonylatedbeta-aminoalcohols.
ChineseJ.Chem.,2006,24,165-168.
10.Ai-XiaWang,Yong-QiangTu,*Zhen-LeiSong,Dao-YiYuan,Xiang-DongHu,Shao-HuaWang,Shuan-HuGao.
SyntheticallyusefulWagner-Meerweinrearrangementofalpha-quaternarybeta-bromovinylmethylethers.
Eur.J.Org.Chem.,2006,12,2691-2694.
11.Xiang-DongHu,Yong-QiangTu,*EnZhang,Shuan-HuGao,Shao-HuaWang,Ai-XiaWang,Chun-AnFan,MinWang.
Totalsynthesisof(±)-galanthamine.
Org.Lett.,2006,8,1823-1825.
12.Shuan-HuGao,Yong-QiangTu,*Xiang-DongHu,Shao-HuaWang,Rong-BaoHua,Yi-JunJiang,Yu-MingZhao,Xiao-HuiFan,Shu-YuZhang.
Generalandefficientstrategyforerythrinanandhomoerythrinanalkaloids:Synthesesof(±)-3-demethoxyerythratidinoneand(±)-erysotramidine.
Org.Lett.,2006,8,2373-2376.
13.Shao-HuaWang,FeiWang,Fu-MinZhang,Chun-AnFan,Yong-QiangTu,*Shi-KuoRen.
Kineticresolutionofbeta-hydroxyepoxidespromotedbychiralaluminiumreagents.
ChineseJ.Org.Chem.,2005,25,1302-1305.
14.MinWang,Bao-MinWang,LeiShi,Yong-QiangTu,*Chun-AnFan,Shao-HuaWang,Xiang-DongHu,Shu-YuZhang.
Quinine/selectfluorcombinationinducedasymmetricsemipinacolrearrangementofallylicalcohols:aneffectiveandenantioselectiveapproachtoalpha-quaternarybeta-fluoroaldehydes.
Chem.Commun.,2005,5580-5582.
15.Pei-NianLiu,Jin-GenDeng,Yong-QiangTu,*Shao-HuaWang.
Highlyefficientandrecyclableheterogeneousasymmetrictransferhydrogenationofketonesinwater.
Chem.Commun.,2004,2070-2071.
16.Xue-QiangLi,HongWang,Yong-QiangTu,*Shao-HuaWang.
SyntheticstudiesoftheHIV-inhibitivemarinenaturalproductssynthesisoftheC1similartoC7fragmentofdidemnaketalA.
ActaChim.Sinica,2004,62,839-841,(2004)
17.FeiWang,Shao-HuaWang,Yong-QiangTu,*Shi-KuoRen.
AlEt3-promotedeliminativering-openingofbeta-hydroxyepoxides:highlystereoselectivesynthesisofterminalalpha-hydroxyolefins.
Tetrahedron-Asymmetry,2003,14,2189-2193.
18.FeiWang,Yong-QiangTu,*Chun-AnFan,Shao-HuaWang,Fu-MinZhang.
Kineticresolutionviasemipinacolrearrangementofalpha-hydroxyepoxides:anewmethodforasymmetricsynthesisofalpha-hydroxyepoxidesandbeta-hydroxyketonescontaininganalpha-quaternarycarbon.
Tetrahedron-Asymmetry,2002,13,395-298.

研究与招生方向

有机合成方法学和天然产物全合成
具有生物（药物）活性的小分子的设计与合成
高通量小分子活性测定方法的设计